A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease
Identifieur interne : 001D70 ( Main/Exploration ); précédent : 001D69; suivant : 001D71A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease
Auteurs : Rachel L. Graham ; Michelle M. Becker ; Lance D. Eckerle ; Meagan Bolles ; Mark R. Denison ; Ralph S. BaricSource :
- Nature Medicine [ 1078-8956 ] ; 2012.
Descripteurs français
- KwdFr :
- Amorces ADN (génétique), Analyse de séquence d'ADN, Animaux, Conception de médicament, Données de séquences moléculaires, Exoribonucleases (antagonistes et inhibiteurs), Exoribonucleases (génétique), Exoribonucleases (métabolisme), Exoribonucleases (physiologie), Facteurs de l'âge, Femelle, Plasmides (génétique), Réaction de polymérisation en chaine en temps réel, Réplication virale (physiologie), Souris, Souris de lignée BALB C, Statistique non paramétrique, Sujet immunodéprimé (immunologie), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Séquence nucléotidique, Vaccins antiviraux (pharmacologie), Virus du SRAS (enzymologie), Virus du SRAS (génétique), Virus du SRAS (pathogénicité).
- MESH :
- antagonistes et inhibiteurs : Exoribonucleases.
- enzymologie : Virus du SRAS.
- génétique : Amorces ADN, Exoribonucleases, Plasmides, Virus du SRAS.
- immunologie : Sujet immunodéprimé, Syndrome respiratoire aigu sévère.
- métabolisme : Exoribonucleases.
- pathogénicité : Virus du SRAS.
- pharmacologie : Vaccins antiviraux.
- physiologie : Exoribonucleases, Réplication virale.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- virologie : Syndrome respiratoire aigu sévère.
- Analyse de séquence d'ADN, Animaux, Conception de médicament, Données de séquences moléculaires, Facteurs de l'âge, Femelle, Réaction de polymérisation en chaine en temps réel, Souris, Souris de lignée BALB C, Statistique non paramétrique, Séquence nucléotidique.
English descriptors
- KwdEn :
- Age Factors, Animals, Base Sequence, DNA Primers (genetics), Drug Design, Exoribonucleases (antagonists & inhibitors), Exoribonucleases (genetics), Exoribonucleases (metabolism), Exoribonucleases (physiology), Female, Immunocompromised Host (immunology), Mice, Mice, Inbred BALB C, Molecular Sequence Data, Plasmids (genetics), Real-Time Polymerase Chain Reaction, SARS Virus (enzymology), SARS Virus (genetics), SARS Virus (pathogenicity), Sequence Analysis, DNA, Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Statistics, Nonparametric, Viral Vaccines (pharmacology), Virus Replication (physiology).
- MESH :
- chemical , antagonists & inhibitors : Exoribonucleases.
- chemical , genetics : DNA Primers, Exoribonucleases.
- chemical , metabolism : Exoribonucleases.
- chemical , pharmacology : Viral Vaccines.
- chemical , physiology : Exoribonucleases.
- drug therapy : Severe Acute Respiratory Syndrome.
- enzymology : SARS Virus.
- genetics : Plasmids, SARS Virus.
- immunology : Immunocompromised Host, Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- physiology : Virus Replication.
- virology : Severe Acute Respiratory Syndrome.
- Age Factors, Animals, Base Sequence, Drug Design, Female, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Real-Time Polymerase Chain Reaction, Sequence Analysis, DNA, Statistics, Nonparametric.
Abstract
Attenuated viruses can be highly effective vaccines. In this issue, Ralph Baric and colleagues report that inactivating mutations in the exonuclease ExoN of a mouse-adapted SARS coronavirus impair replication fidelity and cause a mutator phenotype. The resulting attenuated virus protected mice against a lethal coronavirus challenge.
The online version of this article (doi:10.1038/nm.2972) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nm.2972
PubMed: 23142821
PubMed Central: 3518599
Affiliations:
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Le document en format XML
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type="abstract" xml:lang="en"><p id="Par1">Attenuated viruses can be highly effective vaccines. In this issue, Ralph Baric and colleagues report that inactivating mutations in the exonuclease ExoN of a mouse-adapted SARS coronavirus impair replication fidelity and cause a mutator phenotype. The resulting attenuated virus protected mice against a lethal coronavirus challenge.</p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nm.2972) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jones, Ke" uniqKey="Jones K">KE Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sessa, R" uniqKey="Sessa R">R Sessa</name></author><author><name sortKey="Palagiano, C" uniqKey="Palagiano C">C Palagiano</name></author><author><name sortKey="Scifoni, Mg" uniqKey="Scifoni M">MG Scifoni</name></author><author><name sortKey="Di Pietro, M" uniqKey="Di Pietro M">M di Pietro</name></author><author><name sortKey="Del Piano, M" uniqKey="Del Piano M">M Del Piano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfefferle, S" uniqKey="Pfefferle S">S Pfefferle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vijgen, L" uniqKey="Vijgen L">L Vijgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vignuzzi, M" uniqKey="Vignuzzi M">M Vignuzzi</name></author><author><name sortKey="Wendt, E" uniqKey="Wendt E">E Wendt</name></author><author><name sortKey="Andino, R" uniqKey="Andino R">R Andino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drake, Jw" uniqKey="Drake J">JW Drake</name></author><author><name sortKey="Holland, Jj" uniqKey="Holland J">JJ Holland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holland, Jj" uniqKey="Holland J">JJ Holland</name></author><author><name sortKey="Domingo, E" uniqKey="Domingo E">E Domingo</name></author><author><name sortKey="De La Torre, Jc" uniqKey="De La Torre J">JC de la Torre</name></author><author><name sortKey="Steinhauer, Da" uniqKey="Steinhauer D">DA Steinhauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vignuzzi, M" uniqKey="Vignuzzi 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sortKey="Yount, B" uniqKey="Yount B">B Yount</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Brockway, Sm" uniqKey="Brockway S">SM Brockway</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Becker, Mm" uniqKey="Becker M">MM Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chey, S" uniqKey="Chey S">S Chey</name></author><author><name sortKey="Claus, C" uniqKey="Claus C">C Claus</name></author><author><name sortKey="Liebert, Ug" uniqKey="Liebert U">UG Liebert</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name><name sortKey="Becker, Michelle M" sort="Becker, Michelle M" uniqKey="Becker M" first="Michelle M" last="Becker">Michelle M. Becker</name><name sortKey="Bolles, Meagan" sort="Bolles, Meagan" uniqKey="Bolles M" first="Meagan" last="Bolles">Meagan Bolles</name><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R" last="Denison">Mark R. Denison</name><name sortKey="Eckerle, Lance D" sort="Eckerle, Lance D" uniqKey="Eckerle L" first="Lance D" last="Eckerle">Lance D. Eckerle</name><name sortKey="Graham, Rachel L" sort="Graham, Rachel L" uniqKey="Graham R" first="Rachel L" last="Graham">Rachel L. Graham</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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